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Psychopharmacology revision
1.
Which of the following might be most associated with a 'withdrawal syndrome'
a) SSRIs
b) Tricyclic antidepressants
c) Paroxetine
d) Mirtazepine
e) MAOIs
2.
Which of the following is most associated with agranulocytosis?
a) Risperidone
b) Olanzapine
c) Quetiapine
d) Chlorpromazine
e) Clozapine
3.
Which of the following is a longer acting anxiolytic?
a) Clonazepam
b) Alprazolam
c) Diazepam
d) Oxazepam
e) Lorazepam
4.
Which of the following might be most associated with prolonged QT interval?
a) Rapid dose changes of antipsychotic
b) Pimozide & Antipsychotic
c) Erythromycin & Quetiapine
d) Antipsychotic & Metoclopramide
e) Antipsychotic & Antiepileptics
5.
Which of the following is a monoamine oxidase inhibitor?
a) Citalopram
b) Amitriptyline
c) Phenelzine
d) Venlaflaxine
e) Trazadone
6.
Which of the following may be used in acute management of BPAD?
a) Diazepam
b) Lamotrigine
c) Carbamazepine
d) Gabapentin
e) Topiramate
7.
Which of the following is a tricyclic-related antidepressant?
a) Trazadone
b) Citalopram
c) Venlaflaxine
d) Amitriptyline
e) Phenelzine
8.
Which of the following is most associated with risk of rash, hyponatraemia, and agranulocytosis, and is a potent inducer of CYP450- metabolised by CYP3A4?
a) Carbamazepine
b) Topiramate
c) Lamotrigine
d) Valproate
e) Lithium
9.
What is the reference range for plasma lithium?
a) 0.4-1.0
b) 0.4-0.8
c) 0.8-1.5
d) 0.1-0.4
e) 0.2-0.6
10.
Which of the following is most associated with affecting hepatic function, prothrombin time, is highly protein bound and associated with blood dyscrasias?
a) Lithium
b) Carbamazepine
c) Topiramate
d) Valproate
e) Lamotrigine
11.
Using TCAs & Nitrates together would increase the risk of...
a) Bleeding
b) Cardiotoxicity
c) Sedation
d) Dry mouth
e) Hypertensive crisis
12.
What class of drugs does Reboxetine belong to?
a) NaSSAs
b) SSRI
c) adjunctive therapy for depression
d) NRI
e) SNRI
13.
Acetylcholinesterase inhibitors are used in the treatment of
a) Depression
b) Psychosis
c) Mania
d) Dementia
e) Personality disorder
14.
Which of the following is most associated with elevated triglycerides?
a) Quetiapine
b) Clozapine
c) Risperidone
d) Chlorpromazine
e) Olanzapine
15.
Which of the following is most associated with weight gain?
a) Clozapine
b) Chlorpromazine
c) Quetiapine
d) Risperidone
e) Olanzapine
16.
Which of the following might be most associated with tardive dyskinesia?
a) Pimozide & Antipsychotic
b) Rapid dose changes of Antipsychotic
c) Erythromycin & Quetiapine
d) Long term use of typical Antipsychotic
e) Antipsychotic & Metoclopramide
17.
Which of the following might be most associated with EPSEs?
a) Pimozide & Antipsychotic
b) Antipsychotic & Antiepileptics
c) Antipsychotic & Metoclopramide
d) Risperidone > 6mg/day
e) Clozapine & Carbamazepine
18.
What class of drugs does Tryptophan belong to?
a) NaSSAs
b) SSRI
c) SNRI
d) NRI
e) adjunctive therapy for depression
19.
Which of the following is most associated with QT prolongation?
a) Chlorpromazine
b) Quetiapine
c) Risperidone
d) Clozapine
e) Olanzapine
20.
Using SSRIs & MAOIs together would increase the risk of...
a) Hypertensive crisis
b) Bleeding
c) Cardiotoxicity
d) Dry mouth
e) Sedation
21.
Using anxiolytics/hypnotics with which of the following might be associated with respiratory depression within one hour?
a) TCAs
b) ECT
c) Theophylline
d) IM Olanzapine
e) ACE Inhibitors
22.
Which of the following might be most associated with the side effect: Hypertensive crisis.
a) Tricyclic antidepressants
b) MAOIs
c) Mirtazepine
d) Paroxetine
e) SSRIs
23.
Which of the following is most associated with renal, cardiac, and thyroid complications?
a) Carbamazepine
b) Lamotrigine
c) Lithium
d) Topiramate
e) Valproate
24.
For which of these might anxiolytics/hypnotics be most appropriate?
a) Transient insomnia
b) Severe hepatic impairment
c) Excessive alcohol use
d) Mild insomnia
e) Over 65
25.
Which of the following is most associated with photosensitivity?
a) Risperidone
b) Clozapine
c) Quetiapine
d) Chlorpromazine
e) Olanzapine
26.
Which of the following might be most associated with the side effect: Bleeding disorders.
a) MAOIs
b) Mirtazepine
c) Paroxetine
d) Tricyclic antidepressants
e) SSRIs
27.
Using anxiolytics/hypnotics with which of the following might be associated with sedation?
a) IM Olanzapine
b) ECT
c) Theophylline
d) TCAs
e) ACE Inhibitors
28.
Using anxiolytics/hypnotics with which of the following might be associated with hypotension?
a) ACE Inhibitors
b) TCAs
c) IM Olanzapine
d) ECT
e) Theophylline
29.
Which of the following is an SNRI?
a) Phenelzine
b) Citalopram
c) Amitriptyline
d) Trazadone
e) Venlaflaxine
30.
Donepezil, Galantamine and Rivastigmine are examples of
a) SNRIs
b) mood stabilizers
c) acetylcholinesterase inhibitors
d) antipsychotics
e) tricyclic antidepressants
31.
What class of drugs does Flupentixol belong to?
a) Typical Antipsychotics
b) NaSSAs
c) NRI
d) SSRI
e) SNRI
32.
Using Tramadol & SSRIs toghether would increase the risk of...
a) Dry mouth
b) Cardiotoxicity
c) Sedation
d) Bleeding
e) Serotonin syndrome
33.
Which of the following regimes might most be associated with agranulocytosis?
a) Risperidone > 6mg/day
b) Antipsychotic & Antiepileptics
c) Pimozide & Antipsychotic
d) Antipsychotic & Metoclopramide
e) Clozapine & Carbamazepine
34.
Which of the following might be most associated with the side effect: Cardiotoxicity.
a) SSRIs
b) MAOIs
c) Mirtazepine
d) Tricyclic antidepressants
e) Paroxetine
35.
Which of the following drug treatments would you recommend for newly diagnosed mild depression?
a) Moclobemide
b) None
c) Venlafaxine
d) Dosulepin
e) Fluoxetine
36.
Which of the following is an SSRI?
a) Citalopram
b) Venlaflaxine
c) Trazadone
d) Amitriptyline
e) Phenelzine
37.
Using anxiolytics/hypnotics with which of the following might be associated with hypotension?
a) ECT
b) TCAs
c) Theophylline
d) IM Olanzapine
e) ACE Inhibitors
38.
Which of the following is a tricyclic antidepressant?
a) Phenelzine
b) Trazadone
c) Venlaflaxine
d) Amitriptyline
e) Citalopram
39.
Which of the following might be most associated with the side effect: Dry mouth
a) SSRIs
b) Mirtazepine
c) Paroxetine
d) MAOIs
e) Tricyclic antidepressants
40.
Antipsychotics should be avoided in patients with
a) Lewy Body Dementia
b) Mania
c) Depression
d) Schizophrenia
e) Psychoses
41.
Which of the following is most associated with hypersalivation?
a) Quetiapine
b) Clozapine
c) Chlorpromazine
d) Olanzapine
e) Risperidone
42.
Which of the following is the first line long term treatment for BPAD
a) Lithium
b) Lamotrigine
c) Topiramate
d) Carbamazepine
e) Valproate
43.
Which of the following might be most associated with increased risk of seizures?
a) Antipsychotic & Metoclopramide
b) Erythromycin & Quetiapine
c) Pimozide & Antipsychotic
d) Rapid dose changes of Antipsychotic
e) Long term use of typical Antipsychotic
44.
What class of drugs does Duloxetine belong to?
a) SSRI
b) NaSSAs
c) adjunctive therapy for depression
d) NRI
e) SNRI
45.
Which of the following might be most associated with the side effect: Sedation.
a) SSRIs
b) Paroxetine
c) MAOIs
d) Mirtazepine
e) Tricyclic antidepressants
46.
What class of drugs does Mirtazepine belong to?
a) SNRI
b) NaSSAs
c) NRI
d) SSRI
e) adjunctive therapy for depression
47.
Which of the following might be most associated with the side effect: Increased agitation.
a) MAOIs
b) Tricyclic antidepressants
c) Mirtazepine
d) Paroxetine
e) SSRIs
48.
Using Amiodarone & TCAs together would increase the risk of...
a) Dry mouth
b) Serotonin syndrome
c) Sedation
d) Bleeding
e) Cardiotoxicity
49.
Which of the following might be most associated with cardiotoxicity?
a) Pimozide & Antipsychotic
b) Rapid dose changes of Antipsychotic
c) Clozapine & Carbamazepine
d) Antipsychotic & Metoclopramide
e) Risperidone > 6mg/day
50.
Which of the following is a shorter acting hypnotic?
a) Chlordiazepoxide
b) Clobazam
c) Flurazepam
d) Loprazolam
e) Nitrazepam
51.
What drug should be offered to people with schizophrenia whose illness has not responded adequately to treatment despite the sequential use of adequate doses of at least two different antipsychotic drugs (at least one of which should be a second-generation antipsychotic).
a) Chlorpromazine
b) Olanzapine
c) Risperidone
d) Clozapine
e) Quetiapine
52.
Which of the following is an absolute contraindication to antpsychotic use?
a) phaeochromocytoma
b) angle-closure glaucoma
c) parkinson's disease
d) myasthenia gravis
e) epilepsy
53.
Which of the following may antipsychotics be used to treat?
a) anxiety
b) schizophrenia
c) intractable hiccup
d) all of these
e) mania
54.
Which of the following statements is FALSE?
a) 70% of cases of moderate/severe depression respond to therapy within 6/52
b) Without intervention, the natural course of severe depression is 1-2 months but long term outcome is good
c) Mild depression needs minimal intervention
d) The suicide rate is 15% in severe depression
e) 50% of those with severe depression have recurrent episodes
55.
How many oral antipsychotics are listed in the current British National Formulary?
a) 42
b) 30
c) 23
d) 9
e) 13
56.
With regards ot acetylcholinesetrase inhibitors, which of the following statements is FALSE?
a) They have similar side effect profiles
b) Treatment may improve cognition, approx. equivalent in size to the deterioration expected in 6-12 months of natural decline in untreated patients.
c) They Work to prevent the breakdown of Acetylcholine
d) They start to work immediately
e) They are made from Acetyl Co A and Choline (protein)
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